Genetics, Genomics, & Cancer Biology PhD Program
Faculty
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David Abraham, PhD Professor, Microbiology & Immunology Parasite immunology; role of eosinophils, neutrophils, and macrophages in innate and adaptive immunity to helminth parasite infections; development of vaccines against nematode infections; genetic control of protective immunity to parasites; chemotherapy of leishmaniasis; diagnosis of strongyloidiasis. |
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Emad Alnemri, PhD Professor, Biochemistry & Molecular Biology Molecular mechanisms of programmed cell death (apoptosis); Pattern recognition receptors and inflammasome activation in innate immune responses to molecular danger signals; role of mitochondria in survival, cell death and aging. |
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Andrew E. Aplin, PhD Associate Professor, Cancer Biology Targeting mutant BRAF and integrin signaling in melanoma. |
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Sophie Astrof, PhD Assistant Professor, Medicine The main focus of my lab is to understand cellular and molecular mechanisms of cardiovascular development in vertebrates. |
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Jeffrey L. Benovic, PhD Professor and Chairperson, Biochemistry and Molecular Biology Regulation of receptor signaling, mechanisms of cell migration and chemosensation |
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Bruno Calabretta, MD, PhD Professor, Cancer Biology Molecular mechanisms of normal hematopoiesis and BCR/ABL-dependent leukemogenesis. |
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Teresa Fernandes-Alnemri, PhD Research Assistant Professor, Biochemistry & Molecular Biology The research in my lab focuses on the signaling pathways involved in caspase-1 activation and pro-inflammatory cytokine production by members of the NLR family including NLRP1, NLRP3, NLRC4, NOD1 & NOD2, and the interferon-induced protein AIM2 (absent in melanoma 2). |
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Mark Fortini, PhD Associate Professor, Biochemistry & Molecular Biology Developmental signaling pathways involved in normal cellular patterning and cancer; proteolytic mechanisms in neurogenesis and neurodegeneration; trafficking and post-translational regulation of cell-surface receptors and ligands. |
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Linda E. Greenbaum, MD Associate Professor, Cancer Biology Associate Professor, Medicine Regulation of liver regeneration: role of transcription factors for cell cycle regulation, regulation of hepatocyte proliferation by microRNAs. |
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Ya-ming Hou, PhD Professor, Biochemistry & Molecular Biology Genetic and biochemical studies of tRNA, including structure and function mechanism of tRNA aminoacylation, maintenance of the tRNA 3' end, maturation and processing, editing and repair, decoding on the ribosome, and development of bacterial pathogenesis in infectious diseases; targeting tRNAs as strategies against metabolic and neurodegenerative disorders. |
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James B. Jaynes, PhD Professor, Biochemistry & Molecular Biology Embryos regulate their growth and development in many ways, but control of gene transcription is particularly important for directing cells along particular developmental pathways. |
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Erica S. Johnson, PhD Associate Professor, Biochemistry & Molecular Biology Covalent modifications of proteins play critical roles in most cellular processes through their ability to cause rapid and reversible changes in the functions of pre-existing proteins, multi-protein complexes and subcellular structures. |
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Karen E. Knudsen, PhD Professor, Cancer Biology Translational prostate cancer research, cell cycle control, hormonal control of gene transcription, chromatin remodeling. |
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Lucia R. Languino, PhD Professor, Cancer Biology Studies of the signaling pathways that contribute to prostate cancer progression and metastasis. |
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My Mahoney, PhD Associate Professor, Dermatology & Cutaneous Biology Roles of desmosomal proteins in regulating epithelial cell adhesion, growth and survival; deregulation of desmosomal proteins in autoimmune, infectious, and inherited diseases associated with fragility and abnormality in diverse tissues such as the skin, hair and heart; mechanisms by which desmosomal cadherins can modulate mitogenic signaling pathways; genetically manipulated animal models to study human diseases. |
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Ubaldo Martinez Outschoorn, MD Assistant Professor, Medical Oncology Medical Oncology, Bone Marrow Transplant, Hematologic Malignancies, Leukemia, Lymphoma |
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Alexander M. Mazo, PhD Professor, Biochemistry & Molecular Biology Transcriptional Regulation by Epigenetic Factors and Nuclear Hormone Receptors |
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Steven E. McKenzie, MD, PhD Professor, Medicine and Pediatrics Dr. McKenzie directs two major research projects. The first project involves vascular biology, with a focus on immune-mediated thrombocytopenia and thrombosis syndromes. |
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Steven B. McMahon, PhD Professor, Cancer Biology Our group has a long-standing interest in understanding the biochemical events that are deregulated to cause alterations in broad transcriptional programs in human cancer. |
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Isabelle Mercier, PhD Research Associate Professor, Urology Understanding Hormone-Refractory Cancers (HRC) |
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Diane Merry, PhD Associate Professor, Biochemistry & Molecular Biology Neurodegenerative diseases, Polyglutamine diseases, Androgen receptor structure and function |
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Andrea Morrione, PhD Research Associate Professor, Urology Characterization of Insulin-like Growth Factor Receptor I (IGF-IR) and IR-A (insulin receptor isoform A) function in bladder cancer initiation and progression. Role of the growth factor progranulin (proepithelin) and its receptor in bladder cancer. Characterization of the role of adaptor protein Grb10 in the regulation of IGF-IR and IR-A ubiquitination, trafficking, and signaling. |
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Marja Nevalainen, MD, PhD Associate Professor, Cancer Biology Stat transcription factors in prostate cancer. |
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Richard G. Pestell, MD, PhD Professor & Chairperson, Cancer Biology Molecular mechanisms and gene therapy of breast and prostate cancer; cancer stem cells. |
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Isidore Rigoutsos, PhD Professor & Director, Center for Computational Medicine Pattern discovery; motif discovery; regulatory motifs; microRNAs; miRNAs; piRNAs; microRNA and piRNA targeting; non-coding RNAs; RNAi; RNA interference; retrotransposons; cell process regulation; genomics; computational genetics; computational medicine; diagnostics; therapeutics; high-throughput sequencing analysis; microbial genomics; metagenomics; high performance computing. |
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Natalia A. Riobo, PhD Assistant Professor, Biochemistry & Molecular Biology Signal transduction mechanisms employed by mammalian Hedgehog proteins in cardiomyoctes, endothelium, cancer cells and stromal fibroblasts in the context of cardiovascular regenerative medicine and cancer. |
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Hallgeir Rui, MD, PhD Professor, Cancer Biology Signal transduction and biology of prolactin, growth hormone, and JAK-STAT pathways, with a focus on translational research on drug response prediction in human breast cancer. |
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Linda D. Siracusa, PhD Professor, Microbiology & Immunology Genetics of cancer susceptibility: identification and characterization of genes, allelic variants, and mutations involved in mammalian tumorigenesis. |
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Jouni J. Uitto, MD, PhD Professor and Chairperson, Dermatology & Cutaneous Biology Dr Uitto is internationally recognized for his research on connective tissue biochemistry and molecular biology in relation to cutaneous diseases and skin aging. |
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Ashiwel S. Undieh, PhD Professor and Chairperson, Department of Pharmaceutical Sciences Signal transduction; epigenomics; neuroproteomics; addictive disorder; depressive disorder; animal models |
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Rajanikanth Vadigepalli, PhD Research Assitant Professor, Pathology, Anatomy and Cell Biology Work in Dr. Vadigepalli's lab is directed at understanding the regulatory network dynamics driving the cellular adaptive processes in mammalian pathophysiology. |
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Scott A. Waldman, MD, PhD Professor and Chairperson, Pharmacology & Experimental Therapeutics Molecular mechanisms of signal transduction, with emphasis on receptor-effector coupling and post-receptor signaling mechanisms; molecular mechanisms underlying tissue-specific transcriptional regulation; translation of molecular signaling mechanisms to novel diagnostic and therapeutic approaches to patients with cancer. |
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Chenguang Wang, PhD Associate Professor, Cancer Biology My laboratory focuses on understanding the mechanisms utilized by steroid nuclear receptors in regulation of glucose metabolism, cellular proliferation and cancer progression. |
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Edward Winter, PhD Professor, Biochemistry & Molecular Biology Analysis of meiotic development using molecular genetics in yeast; signal transduction and protein kinases; transcriptional regulation. |
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Teresa Zimmers, PhD Associate Professor, Cancer Biology The overall aim of my research is to understand the molecular mechanisms regulating organ size. The model system and application we have chosen to study is regulation of skeletal muscle mass in disease. |
