Dr. Mahoney My Mahoney, PhD

Contact Dr. Mahoney

233 South 10th Street
Room 428
Philadelphia, PA 19107

(215) 503-4632
(215) 923-1098 fax

Research and Clinical Interests
Roles of desmosomal proteins in regulating epithelial cell adhesion, growth and survival; deregulation of desmosomal proteins in autoimmune, infectious, and inherited diseases associated with fragility and abnormality in diverse tissues such as the skin, hair and heart; mechanisms by which desmosomal cadherins can modulate mitogenic signaling pathways; genetically manipulated animal models to study human diseases.

Publications

Most recent Peer-reviewed Publications

  1. Lipid rafts and detergent-resistant membranes in epithelial keratinocytes
  2. Palmitoylation of plakophilin is required for desmosome assembly
  3. Reduced fibulin-2 contributes to loss of basement membrane integrity and skin blistering in mice lacking integrin α3β1 in the epidermis
  4. Expression of p53 protein after nonablative rejuvenation: The other side of the coin
  5. Efficacy of mesotherapy in facial rejuvenation: A histological and immunohistochemical evaluation
  6. Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca 2+/Mn 2+ ATPase SPCA1 in cultured keratinocytes
  7. Multiple minimally invasive Erbium: Yttrium Aluminum Garnet laser mini-peels for skin rejuvenation: An objective assessment
  8. A role for caveolin-1 in desmoglein binding and desmosome dynamics
  9. Noncanonical Hedgehog Signaling
  10. Effects of the Nd:YAG 1320-nm laser on skin rejuvenation: Clinical and histological correlations
  11. Radiofrequency facial rejuvenation: Evidence-based effect
  12. Electro-optical synergy technique a new and effective nonablative approach to skin aging
  13. Compound heterozygous desmoplakin mutations result in a phenotype with a combination of myocardial, skin, hair, and enamel abnormalities
  14. Superficial Dsg2 expression limits epidermal blister formation mediated by pemphigus foliaceus antibodies and exfoliative toxins
  15. Desmosomes and desmosomal cadherin function in skin and heart diseases - Advancements in basic and clinical research
  16. Extracellular matrix in cutaneous ageing: The effects of 0.1% copper-zinc malonate-containing cream on elastin biosynthesis
  17. Increased expression of Dsg2 in malignant skin carcinomas: A tissue-microarray based study
  18. Deregulation of keratinocyte differentiation and activation: A hallmark of venous ulcers (Journal of Cellular and Molecular Medicine (2008) 12, 6B, (2675-2690)
  19. Deregulation of keratinocyte differentiation and activation: A hallmark of venous ulcers
  20. Decreased plakophilin-1 expression promotes increased motility in head and neck squamous cell carcinoma cells

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