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Thomas Jefferson University - Renato Baserga, M.D.
Renato Baserga, M.D.

Cancer Biology
Thomas Jefferson University
Jefferson Medical College
Department of Cancer Biology
Distinguished Professor

Mailing Address
Kimmel Cancer Center
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: (215) 503-4507
Fax: (215) 923-0249
renato.baserga@jefferson.edu
Expertise and Research Interests
My research focuses on the type 1 insulin-like growth factor receptor (IGF-IR), a receptor that plays important roles in the growth, differentiation and malignant transformation of cells. Like all growth factor receptors, it is activated by ligands, in this case, three ligands, IGF-I, IGF-II and insulin. When activated, the IGF-IR also sends a strong anti-apoptotic signal. As a corollary, down-regulation of the IGF-IR leads to massive apoptosis, especially of tumor cells. Several patents on targeting of the IGF-IR have been filed by Thomas Jefferson University and my group, and two of these patents are developed by biotech and pharmaceutical companies.

In the laboratory, the present interests deal with signal transduction from the IGF-IR and the mechanism by which it activates various genetic programs in the cell.
Keywords
Aging; Biochemistry; Biological Signal Transduction; Biomedical Facility; Biophysics; Cell Biology; Cell Cycle Protein; Cell Differentiation; Cell Growth Regulation; Cell Senescence; Complementary Dna; Developmental Biology; Developmental Neurobiology; Diploidy; Dna Binding Protein; Dna Replication; Epidermal Growth Factor; Ethanol; Fibroblast; Gel Electrophoresis; Gene Expression; Genetic Mapping; Genetic Promoter Element; Genetic Regulation; Genetic Regulatory Element; Genetic Transcription; Genetics; Growth Factor Receptor; Growth Inhibitor; Human Physiology; Immortalized Cell; Insulinlike Growth Factor; Messenger Rna; Microinjection; Mitogen; Molecular Biology; Molecular Cloning; Molecular Genetics; Molecular Site; Northern Blotting; Nuclear Runoff Assay; Nucleic Acid Sequence; Oncogene; Pharmacology; Platelet Derived Growth Factor; Polymerase Chain Reaction; Proliferating Cell Nuclear Antigen; Protein Biosynthesis; Protein Purification; Protein Sequence; Protooncogene; Receptor Binding; Receptor Expression; Simian Virus; Structural Gene; Temperature Sensitive Mutant; Tissue Cell Culture; Transcription Factor; Transfection; Virus Antigen; Wi
Publications
  • Baserga, R. The insulin-like growth factor-1 receptor as a target for cancer therapy. Expert Opinion on Therapeutic Targets, in press 2005.

  • Chen, J., Wu, A., Drakas, R., Garofalo, C., Cascio, S., Surmacz, E. and Baserga, R. Functional Significance of IGF-1-Mediated Nuclear Translocation of the Insulin Receptor Substrate-1 and b-Catenin. Journal of Biological Chemistry, Jun 2005;10.1074/jbc.M504516200.

  • Liu, M., Prisco, M., Drakas, R., Searles, D. and Baserga, R. 24p3 in Differentiation of Myeloid Cells. J. Cell Physiology, in press 2005.

  • Wu, A., Tu, X., Prisco, M. and Baserga, R. Regulation of Upstream Binding Factor 1 Activity by IGF-I Receptor Signaling. Journal of Biological Chemistry, 280:2863-2872, 2005.

  • Drakas, R., Prisco, M. and Baserga, R. A Modified TAP tag Technique for the Purification of Protein Complexes in Mammalian Cells. Proteomics, 5:132-137, 2005.

  • Prisco, M., Maiorana, A., Guerzoni, C., Calin, G., Calabretta, B., Voit, R., Grummt, I. and Baserga, R. The Role of Pescadillo and Upstream Binding Factor in the Proliferation and Differentiation of Murine Myeloid Cells. Molecular and Cellular Biology, 24:5421-5433, 2004.

  • Drakas, R., Tu, X. and Baserga, R. Control of Cell Size through Phosphorylation of UBF1 by Nuclear PI-3 Kinase. PNAS, 101:9272-9276, 2004.

  • Baserga, R. Targeting the IGF-1 receptor: from rags to riches. European Journal of Cancer, 40:2013-2015, 2004.

  • Maoirana, A., Cheng, G. and Baserga, R. Role of Pescadillo in the Transformation and Immortalization of Mammalian Cells. Oncogene, 23:7116-7124, 2004.

  • Sun, H. and Baserga, R. Deletion of the Pleckstrin and Phosphotyrosine Binding Domains of Insulin Receptor Substrate-2 Does Not Impair its Ability to Regulate Cell Proliferation in Myeloid Cells. Endocrinology, 145:5332-5343, 2004.

  • Sun, H-Z, Tu, X., Wu, A., Prisco, M., Casaburi, I., and Baserga, R. Insulin-like Growth Factor I Receptor Signaling and Nuclear Translocation of Insulin Receptor Substrates 1 and 2. Molecular Endocrinology 17(3):472-486, 2003.

  • Wu, A, Sciacca, L, and Baserga, R. Nuclear Translocation of Insulin Receptor Substrate-1 by the Insulin Receptor in Mouse Embryo Fibroblasts. Journal of Cellular Physiology, 195:453-460, 2003.

  • Sciacca, L, Prisco, M, Wu, A, Belfiore, A, Vigneri, R, and Baserga, R. Signaling Differences from the A and B Isoforms of the Insulin Receptor in 32D Cells in the Presence or Absence of IRS-1. Endocrinology, 144:2650-2658, 2003.

  • Tu, X, Baffa, R, Luke, S, Prisco, M, and Baserga, R. Intracellular Redistribution of Nuclear and Nucleolar Proteins during Differentiation of 32D Murine Hemopoietic Cells. Experimental Cell Research, 288:119-130, 2003.

  • Baserga, R., Peruzzi, F., Reiss, K. IGF-1 Receptor in Cancer Biology. Int. J. Cancer, 107:873-877, 2003.

  • Tu, X, Wu, A, Maiorana, A, and Baserga, R. Subcellular Localization of IRS-1 in Cell Proliferation and Differentiation. Hormone and Metabolic Research, 35:734-739, 2003.

  • Belletti, B., Drakas, R., Morrione, A., Tu, X, Casaburi, I. and Baserga, R. Regulation of ID1 Protein Expression in Mouse Embryo Fibroblasts by the Type 1 Insulin-like Growth Factor Receptor. Exp. Cell Res. 277:107-118, 2002.

  • Prisco, M., Santini, F., Baffa, R., Liu, M., Drakas, R., Wu, A. and Baserga, R. Nuclear translocation of Insulin Receptor Substrate-1 by the Simian Virus 40 T Antigen and the Activated Type 1 Insulin-like Growth Factor Receptor. JBC 277:32078-32085, 2002.

  • Tu, X., Batta, P., Innocent, N., Prisco, M., Casaburi, I., Belletti, B. and Baserga, R. Nuclear Translocation of Insulin Receptor Substrate-1 by Oncogenes and IGF-I: Effect on Ribosomal RNA Synthesis. JBC 277:44357-44365, 2002.

  • Peretz, S., Kim, C., Rockwell, S., Baserga, R. and Glazer, P.M. IGF1 Receptor Expression Protects against Microenvironmental Stress Found in the Solid Tumor. Radiation Research 159:174-180, 2002.

  • Navarro, M. and Baserga, R. Limited Redundancy of Survival Signals from the Type 1 Insulin-Like Growth Factor Receptor. Endocrinology 142:1073-1081, 2001.

  • Reiss, K., Wang, J-Y., Romano, G., Tu, X., Peruzzi, F., and Baserga, R. Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells. Oncogene 20:490-500, 2001.

  • Romano, G., Reiss, K., Tu, X., Peruzzi, F., Belletti, B., Wang, J. Y., Zanocco-Marani, T., and Baserga, R. Efficient in vitro and in vivo gene regulation of a retrovirally delivered pro-apoptotic factor under the control of the Drosophila HSP70 promoter. Gene Therapy 8:600-607, 2001.

  • Peretz, S., Jensen, R., Baserga, R., and Galzer, P.M. ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proc. Natl. Acad. Sci. 98:1676-1681, 2001.

  • Andrews, D. W., Resniocoff, M., Flanders, A. E., Kenyon, L., Curtis, M., Merli, G., Baserga, R., Iliakis, G., and Aiken, R. D. Results of a Pilot Study Involving the Use of an Antisense Oligodeoxynucleotide Directed Against the Insulin-Like Growth Factor Type I Receptor in Malignant Astrocytomas. J. Clinical Oncology 19:2189-2200, 2001.

  • Belletti, B., Prisco, M., Morrione, A., Valentinis, B., Navarro, M., and Baserga, R. Regulation of Id2 Gene Expression by the Insulin-like Growth Factor I Receptor Requires signaling by Phosphatidylinositol 3-Kinase. J. Biol. Chem. 276:13867-13874, 2001.

  • Peruzzi F., Prisco M., Morrione A., Valentinis B., and Baserga R. Anti-apoptotic Signaling of the Insulin-like Growth Factor-I Receptor through Mitochondrial Translocation of c-Raf and Nedd4. J. Biol. Chem. 276:25990-25996, 2001.

  • Reiss K., Tu X., Romano G., Peruzzi F., Wang JY., and Baserga R. Intracellular Association of a Mutuant Insulin-like Growth Factor Receptor with Endogenous Receptors. Clin. Can. Res. 7:2134-2144, 2001.

  • Prisco M., Peruzzi F., Belletti B., and Baserga R.. Regulation of Id Gene Expression by the Type I Insulin-like Growth Factor: Roles of STAT3 and the Tyrosine 950 Residue of the Receptor. Mol. Cell. Biol. 21:5447-5458, 2001.

  • Valentinis B., and Baserga R. IGF-I receptor signalling in transformation and differentiation. J Clin. Pathol: Mol. Path. 54:133-137, 2001.

  • Morrione A., Navarro M., Romano G., Dews M., Reiss K., Valentinis B., Belletti B., and Baserga R. The Role of the Insulin Receptor Substrate-1 in the Differentiation of Rat Hippocampal Neuronal Cells. Oncogene 20:4842-4852, 2001.

  • Navarro, M., Valentinis, B., Belletti, B., Romano, G., Reiss, K., and Baserga, R. Regulation of Id2 Gene Expression by the Type 1 IGF Receptor and the Insulin Receptor Substrate-1. Endocrinology 142:5149-5157, 2001.

  • Dews, M., Prisco, M., Peruzzi, F., Romano, G, Morrione, A., Baserga, R.: Domains of the IGF-I Receptor Required for the Activation of Extracellular Signal-Regulated Kinases. Endocrinology 141:1289-1300, 2000.

  • Morrione, A., Romano, G., Navarro, M., Reiss, K., Valentinis, B., Dews, M., Eves, E., Rich Rosner, M., Baserga, R. Insulin-like Growth Factor-1 Receptor Signaling in Differentation of Neuronal H19-7 Cells. Cancer Research 60:2263-2272, 2000.

  • Reiss, K., Wang, JY., Romano G., Furnari FB., Cavenee WK., Morrione A., Tu X. and Baserga R. IGF-I receptor signaling in a prostate cancer cell line with a PTEN mutation. Oncogene, 19:2687-2694, 2000.

  • Valentinis B, Navarro M, Zanocco-Marani T, Edmonds P, McCormick J, Morrione A, Sacchi A, Romano G, Reiss K and Baserga R: Insulin Receptor Substrate-1, p70S6K and Cell Size in Transformation and Differentiation of Hemopoietic Cells. J. Biol. Chem 275:25451-25459, 2000.

  • Gatzka M., Prisco M., Baserga, R. Stabilization of the ras oncoprotein by the insulin-like growth factor 1 receptor during anchorage-independent growth. Cancer Res. 60:4222-4230, 2000.

  • Cristofanelli, B., Valentinis, B., Soddu, S., Rizzo, M. G., Marchetti, A., Bossi, G., Morena, A. R., Dews, M., Baserga, R., and Sacchi, A. Cooperative transformation of 32D cells by the combined expression of IRS-1 and V-Ha-Ras. Oncogene 19:3245-3255, 2000.

  • Baserga, R. The contradiction of the insulin-like growth factor 1 receptor. Oncogene 19:5574-5581, 2000.

  • Reiss K, Yumet G, Shan S, Huang Z, Alnemri E, Srinivasula SM, Wang JY, Morrione A, Baserga R. Synthetic peptide sequence from the C-terminus of the insulin-like growth factor-I receptor that induces apoptosis and inhibition of tumor growth. Journal of Cell Physiology. 181(1): 124-35, Oct 1999

  • Peruzzi F, Prisco M, Dews M, Salomoni P, Grassilli E, Romano G, Calabretta B, Baserga R. Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Molecular and Cellular Biology. 19(10): 7203-15, Oct 1999

  • Morrione A; Plant P; Valentinis B; Staub O; Kumar S; Rotin D; Baserga R. mGrb10 interacts with Nedd4. Journal of Biological Chemistry. 274(34): 24094-9, 20 Aug 1999

  • Valentinis B, Romano G, Peruzzi F, Morrione A, Prisco M, Soddu S, Cristofanelli B, Sacchi A, Baserga R. Growth and differentiation signals by the insulin-like growth factor 1 receptor in hemopoietic cells are mediated through different pathways. Journal of Biological Chemistry. 274(18): 12423-30, 30 Apr 1999

  • Valentinis B, Morrione A, Peruzzi F, Prisco M, Reiss K, Baserga R. Anti-apoptotic signaling of the IGF-I receptor in fibroblasts following loss of matrix adhesion. Oncogene. 18(10): 1827-36, 11 Mar 1999

  • Reiss K, D'Ambrosio C, Tu X, Tu C, Baserga R. Inhibition of tumor growth by a dominant negative mutant of the insulin-like growth factor I receptor with a bystander effect. Clinical Cancer Research. 4(11): 2647-55, Nov 1998

  • Valentinis B,Reiss K,Baserga R. Insulin-like growth factor-I-mediated survival from anoikis: role of cell aggregation and focal adhesion kinase. Journal of Cellular Physiology. 176(3): 648-57, Sep 1998

  • Xu SQ,Tang D,Chamberlain S,Pronk G,Masiarz FR,Kaur S,Prisco M,Zanocco-Marani T,Baserga R. The granulin/epithelin precursor abrogates the requirement for the insulin-like growth factor 1 receptor for growth in vitro. Journal of Biological Chemistry. 273(32): 20078-83, Aug 1998

  • Reiss K,Valentinis B,Tu X,Xu SQ,Baserga R. Molecular markers of IGF-I-mediated mitogenesis. Experimental Cell Research. 242(1): 361-72, 10 Jul 1998

  • Hongo A,Yumet G,Resnicoff M,Romano G,O'Connor R,Baserga R. Inhibition of tumorigenesis and induction of apoptosis in human tumor cells by the stable expression of a myristylated COOH terminus of the insulin-like growth factor I receptor. Cancer Research. 58(11): 2477-84, Jun 1998

  • Resnicoff M,Valentinis B,Herbert D,Abraham D,Friesen P D,Alnemri E S,Baserga R. The baculovirus anti-apoptotic p35 protein promotes transformation of mouse embryo fibroblasts. Journal of Biological Chemistry. 273(17): 10376-80, 24 Apr 1998

  • Resnicoff M,Baserga R. The role of the insulin-like growth factor I receptor in transformation and apoptosis. Annals of The New York Academy of Sciences. 842: 76-81, 15 Apr 1998

  • Resnicoff M,Huang Z,Herbert D,Abraham D,Baserga R. A novel class of peptides that induce apoptosis and abrogate tumorigenesis in vivo. Biochemical and Biophysical Research Communications. 240(1): 208-12, Nov 1997

  • Morrione A,Valentinis B,Resnicoff M,Xu Sq,Baserga R. The role of mGrb10alpha in insulin-like growth factor I-mediated growth. Journal of Biological Chemistry. 272(42): 26382-7, 17 Oct 1997

  • Li Q,Li B,Wang X,Leri A,Jana KP,Liu Y,Kajstura J,Baserga R,Anversa P. Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. Journal of Clinical Investigation. 100(8): 1991-9, 15 Oct 1997

  • Baserga R. The price of independence. Experimental Cell Research. 236(1): 1-3, 10 Oct 1997

  • Miura M,Baserga R. The tyrosine residue at 1250 of the insulin-like growth factor I receptor is required for ligand-mediated internalization. Biochemical and Biophysical Research Communications. 239(1): 182-5, Oct 1997

  • Zhou-Li F,Xu S Q,Dews M,Baserga R. Co-operation of simian virus 40 T antigen and insulin receptor substrate-1 in protection from apoptosis induced by interleukin-3 withdrawal. Oncogene. 15(8): 961-70, 18 Aug 1997

  • D'Ambrosio C,Valentinis B,Prisco M,Reiss K,Rubini M,Baserga R. Protective effect of the insulin-like growth factor I receptor on apoptosis induced by okadaic acid. Cancer Research. 57(15): 3264-71, Aug 1997

  • Baserga R,Resnicoff M,Dews M. The IGF-I receptor and cancer. Endocrine. 7(1): 99-102, Aug 1997

  • Turner BC,Haffty BG,Narayanan L,Yuan J,Havre PA,Gumbs AA,Kaplan L,Burgaud JL,Carter D,Baserga R,Glazer PM. Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Research. 57(15): 3079-83, Aug 1997

  • Valentinis B,Morrione A,Taylor SJ,Baserga R. Insulin-like growth factor I receptor signaling in transformation by src oncogenes. Molecular and Cellular Biology. 17(7): 3744-54, Jul 1997

  • Xu SQ,Sell C,DuBois GC,Baserga R. A novel growth stimulating activity from BRL-3A cell conditioned medium. Cell Proliferation. 30(6-7): 295-307, Jun 1997

  • Baserga R,Hongo A,Rubini M,Prisco M,Valentinis B. The IGF-I receptor in cell growth, transformation and apoptosis. Biochimica Et Biophysica Acta. 1332(3): F105-26, Jun 1997

  • Baserga R. The path less traveled by [editorial, comment]. Endocrinology. 138(6): 2217-8, Jun 1997

  • Dumenil G,Rubini M,Dubois G,Baserga R,Fellous M,Pellegrini S. Identification of signalling components in tyrosine kinase cascades using phosphopeptide affinity chromatography. Biochemical and Biophysical Research Communications. 234(3): 748-53, 29 May 1997

  • Morrione A,Valentinis B,Xu SQ,Yumet G,Louvi A,Efstratiadis A,Baserga R. Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Proceedings of the National Academy of Sciences (USA). 94(8): 3777-82, 15 Apr 1997

  • Prisco M,Hongo A,Rizzo MG,Sacchi A,Baserga R. The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal. Molecular and Cellular Biology. 17(3): 1084-92, Mar 1997

  • Rubini M,Hongo A,D'Ambrosio C,Baserga R. The IGF-I receptor in mitogenesis and transformation of mouse embryo cells: role of receptor number. Experimental Cell Research. 230(2): 284-92, Feb 1997

  • O'Connor R,Kauffmann-Zeh A,Liu Y,Lehar S,Evan GI,Baserga R,Blattler WA. Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis. Molecular and Cellular Biology. 17(1): 427-35, Jan 1997

  • Baserga R,Resnicoff M,D'Ambrosio C,Valentinis B. The role of the IGF-I receptor in apoptosis. Vitamins and Hormones. 53: 65-98, 1997

  • Dews M,Nishimoto I,Baserga R. IGF-I receptor protection from apoptosis in cells lacking the IRS proteins. Receptors and Signal Transduction. 7(4): 231-40, 1997

  • Resnicoff M,Tjuvajev J,Rotman HL,Abraham D,Curtis M,Aiken R,Baserga R. Regression of C6 rat brain tumors by cells expressing an antisense insulin-like growth factor I receptor RNA. Journal of Experimental Therapeutics and Oncology. 1(6): 385-9, Nov 1996

  • Steller MA, Zou Z, Schiller JT, Baserga R. Transformation by human papillomavirus 16 E6 and E7: role of the insulin-like growth factor 1 receptor. Cancer Research. 56(21): 5087-91, Nov 1996

  • D'Ambrosio C;Ferber A;Resnicoff M;Baserga R. A soluble insulin-like growth factor I receptor that induces apoptosis of tumor cells in vivo and inhibits tumorigenesis. Cancer Research. 56(17): 4013-20, 1 Sep 1996

  • Pass H I,Mew D J,Carbone M,Matthews W A,Donington J S,Baserga R,Walker C L,Resnicoff M,Steinberg S M. Inhibition of hamster mesothelioma tumorigenesis by an antisense expression plasmid to the insulin-like growth factor-1 receptor. Cancer Research. 56(17): 4044-8, Sep 1996

  • Reiss K;Cheng W;Ferber A;Kajstura J;Li P;Li B;Olivetti G;Homcy C J;Baserga R;Anversa P. Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice. Proceedings of the National Academy of Sciences (USA). 93(16): 8630-5, 6 Aug 1996

  • Valentinis B,Baserga R. The IGF-I receptor protects tumor cells from apoptosis induced by high concentrations of serum. Biochemical and Biophysical Research Communications. 224(2): 362-8, 16 Jul 1996

  • Morrione A;Valentinis B;Li S;Ooi J Y;Margolis B;Baserga R. Grb10: A new substrate of the insulin-like growth factor I receptor. Cancer Research. 56(14): 3165-7, 15 Jul 1996

  • Li S;Resnicoff M;Baserga R. Effect of mutations at serines 1280-1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptor. Journal of Biological Chemistry. 271(21): 12254-60, 24 May 1996

  • Baserga R. Controlling IGF-receptor function: a possible strategy for tumor therapy. Trends In Biotechnology. 14(5): 150-2, May 1996

  • Hongo A;D'Ambrosio C;Miura M;Morrione A;Baserga R. Mutational analysis of the mitogenic and transforming activities of the insulin-like growth factor I receptor. Oncogene. 12(6): 1231-8, 21 Mar 1996

  • Burgaud JL,Baserga R. Intracellular transactivation of the insulin-like growth factor I receptor by an epidermal growth factor receptor. Experimental Cell Research. 223(2): 412-9, 15 Mar 1996

  • D'Ambrosio C;Hongo A;Li S;Baserga R. The role of Grb2 in the growth and transformation of mouse embryo cells. Oncogene. 12(2): 371-8, 18 Jan 1996

  • Li S;Baserga R. Epidermal growth factor and platelet-derived growth factor regulate the activity of the insulin-like growth factor I gene promoter. Experimental Gerontology. 31(1-2): 195-206, Jan 1996

  • Resnicoff M;Li W;Basak S;Herlyn D;Baserga R;Rubin R. Inhibition of rat C6 glioblastoma tumor growth by expression of insulin-like growth factor I receptor antisense mRNA. Cancer Immunology, Immunotherapy. 42(1): 64-8, Jan 1996

  • Morrione A;DeAngelis T;Baserga R. The GC factor regulates the expression of the insulin-like growth factor-I receptor. Cell Proliferation. 28(12): 659-71, Dec 1995

  • Hayry P;Myllarniemi M;Aavik E;Alatalo S;Aho P;Yilmaz S;Raisanen-Sokolowski A;Cozzone G;Jameson B A;Baserga R. Stabile D-peptide analog of insulin-like growth factor-1 inhibits smooth muscle cell proliferation after carotid ballooning injury in the rat. Faseb Journal. 9(13): 1336-44, Oct 1995

  • Miura M;Surmacz E;Burgaud J L;Baserga R. Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor. Journal of Biological Chemistry. 270(38): 22639-44, 22 Sep 1995

  • Burgaud J L;Resnicoff M;Baserga R. Mutant IGF-I receptors as dominant negatives for growth and transformation. Biochemical and Biophysical Research Communications. 214(2): 475-81, 14 Sep 1995

  • Resnicoff M;Burgaud J L;Rotman H L;Abraham D;Baserga R. Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor I receptors. Cancer Research. 55(17): 3739-41, 1 Sep 1995

  • Rubin R;Baserga R. Insulin-like growth factor-I receptor. Its role in cell proliferation, apoptosis, and tumorigenicity. Laboratory Investigation. 73(3): 311-31, Sep 1995

  • Morrione A;DeAngelis T;Baserga R. Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes. Journal of Virology. 69(9): 5300-3, Sep 1995

  • Fei Z L;D'Ambrosio C;Li S;Surmacz E;Baserga R. Association of insulin receptor substrate 1 with simian virus 40 large T antigen. Molecular and Cellular Biology. 15(8): 4232-39, Aug 1995

  • DeAngelis T;Ferber A;Baserga R. Insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the platelet-derived growth factor receptor. Journal of Cellular Physiology. 164(1): 214-21, Jul 1995

  • Resnicoff M;Abraham D;Yutanawiboonchai W;Rotman H L;Kajstura J;Rubin R;Zoltick P;Baserga R. The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer Research. 55(11): 2463-9, 1 Jun 1995

  • D'Ambrosio C;Keller S R;Morrione A;Lienhard G E;Baserga R;Surmacz E. Transforming potential of the insulin receptor substrate 1. Cell Growth and Differentiation. 6(5): 557-62, May 1995

  • Surmacz E;Sell C;Swantek J;Kato H;Roberts C T Jr;LeRoith D;Baserga R. Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor. Experimental Cell Research. 218(1): 370-80, May 1995

  • Long L;Rubin R;Baserga R;Brodt P. Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor. Cancer Research. 55(5): 1006-9, 1 Mar 1995

  • Valentinis B;Bhala A;DeAngelis T;Baserga R;Cohen P. The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene. Molecular Endocrinology. 9(3): 361-7, Mar 1995

  • Miura M;Li S;Baserga R. Effect of a mutation at tyrosine 950 of the insulin-like growth factor I receptor on the growth and transformation of cells. Cancer Research. 55(3): 663-7, 1 Feb 1995

  • Sell C;Baserga R;Rubin R. Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis. Cancer Research. 55(2): 303-6, 15 Jan 1995

  • Baserga R. The insulin-like growth factor I receptor: a key to tumor growth?. Cancer Research. 55(2): 249-52, 15 Jan 1995

  • LeRoith D;Baserga R;Helman L;Roberts C T Jr. Insulin-like growth factors and cancer [see comments]. Annals of Internal Medicine. 122(1): 54-9, 1 Jan 1995

  • Li S;Ferber A;Miura M;Baserga R. Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain. Journal of Biological Chemistry. 269(51): 32558-64, 23 Dec 1994

  • Baserga R. Oncogenes and the strategy of growth factors. Cell. 79(6): 927-30, 16 Dec 1994

  • Resnicoff M;Rubini M;Baserga R;Rubin R. Ethanol inhibits insulin-like growth factor-1-mediated signalling and proliferation of C6 rat glioblastoma cells. Laboratory Investigation. 71(5): 657-62, Nov 1994

  • Resnicoff M;Coppola D;Sell C;Rubin R;Ferrone S;Baserga R. Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor. Cancer Research. 54(18): 4848-50, 15 Sep 1994

  • Porcu P;Grana X;Li S;Swantek J;De Luca A;Giordano A;Baserga R. An E2F binding sequence negatively regulates the response of the insulin-like growth factor 1 (IGF-I) promoter to simian virus 40T antigen and to serum. Oncogene. 9(8): 2125-34, Aug 1994

  • Coppola D;Ferber A;Miura M;Sell C;D'Ambrosio C;Rubin R;Baserga R. A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor. Molecular and Cellular Biology. 14(7): 4588-95, Jul 1994

  • Charollais R H;Surmacz E;Baserga R. Introns determine the time of appearance of PCNA mRNA in 3T3 cells stimulated by growth factors. Biochemical and Biophysical Research Communications. 201(2): 841-7, 15 Jun 1994

  • Sell C;Dumenil G;Deveaud C;Miura M;Coppola D;DeAngelis T;Rubin R;Efstratiadis A;Baserga R. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Molecular and Cellular Biology. 14(6): 3604-12, Jun 1994

  • Miura M;Li S W;Dumenil G;Baserga R. Platelet-derived growth factor-induced expression of messenger RNA for the proliferating cell nuclear antigen requires a functional receptor for the insulin-like growth factor I. Cancer Research. 54(9): 2472-7, 1 May 1994

  • Resnicoff M;Sell C;Rubini M;Coppola D;Ambrose D;Baserga R;Rubin R. Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors. Cancer Research. 54(8): 2218-22, 15 Apr 1994

  • Rubini M;Werner H;Gandini E;Roberts C T Jr;LeRoith D;Baserga R. Platelet-derived growth factor increases the activity of the promoter of the insulin-like growth factor-1 (IGF-1) receptor gene. Experimental Cell Research. 211(2): 374-9, Apr 1994

  • Ambrose D;Resnicoff M;Coppola D;Sell C;Miura M;Jameson S;Baserga R;Rubin R. Growth regulation of human glioblastoma T98G cells by insulin-like growth factor-1 and its receptor. Journal of Cellular Physiology. 159(1): 92-100, Apr 1994

  • Valentinis B;Porcu P L;Quinn K;Baserga R. The role of the insulin-like growth factor I receptor in the transformation by simian virus 40 T antigen. Oncogene. 9(3): 825-31, Mar 1994

  • Baserga R; Sell C; Porcu P; Rubini M. The role of the IGF-I receptor in the growth and transformation of mammalian cells. Cell Proliferation. 27(2): 63-71, Feb 1994

  • Sell C;Rubini M;Rubin R;Liu J P;Efstratiadis A;Baserga R. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proceedings of the National Academy of Sciences (USA). 90(23): 11217-21, 1 Dec 1993

  • Resnicoff M;Sell C;Ambrose D;Baserga R;Rubin R. Ethanol inhibits the autophosphorylation of the insulin-like growth factor 1 (IGF-1) receptor and IGF-1-mediated proliferation of 3T3 cells. Journal of Biological Chemistry. 268(29): 21777-82, 15 Oct 1993

  • Yoshinouchi M;Miura M;Gaozza E;Li S W;Baserga R. Basic fibroblast growth factor stimulates DNA synthesis in cells overexpressing the insulin-like growth factor-I receptor. Molecular Endocrinology. 7(9): 1161-8, Sep 1993

  • Baserga R. Gene regulation by IGF-I. Molecular Reproduction and Development. 35(4): 353-6; discussion 35, Aug 1993

  • Sell C;Ptasznik A;Chang C D;Swantek J;Cristofalo V J;Baserga R. IGF-1 receptor levels and the proliferation of young and senescent human fibroblasts. Biochemical and Biophysical Research Communications. 194(1): 259-65, 15 Jul 1993

  • Pietrzkowski Z;Mulholland G;Gomella L;Jameson B A;Wernicke D;Baserga R. Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1. Cancer Research. 53(5): 1102-6, 1 Mar 1993

  • Yoshinouchi M;Baserga R. The role of the IGF-1 receptor in the stimulation of cells by short pulses of growth factors. Cell Proliferation. 26(2): 139-46, Mar 1993

  • Colige A;Sokolov B P;Nugent P;Baserga R;Prockop D J. Use of an antisense oligonucleotide to inhibit expression of a mutated human procollagen gene (COL1A1) in transfected mouse 3T3 cells. Biochemistry. 32(1): 7-11, 12 Jan 1993

  • Baserga R;Porcu P;Sell C. Oncogenes, growth factors and control of the cell cycle. Cancer Surveys. 16: 201-13, 1993

  • Baserga R;Rubin R. Cell cycle and growth control. Critical Reviews In Eukaryotic Gene Expression. 3(1): 47-61, 1993

  • Baserga R;Porcu P;Rubini M;Sell C. Cell cycle control by the IGF-1 receptor and its ligands. Advances In Experimental Medicine and Biology. 343: 105-12, 1993

  • Pietrzkowski Z;Wernicke D;Porcu P;Jameson B A;Baserga R. Inhibition of cellular proliferation by peptide analogues of insulin-like growth factor 1. Cancer Research. 52(23): 6447-51, 1 Dec 1992

  • Baserga R. IGF-1 receptor as the restriction point of the cell cycle. Annals of The New York Academy of Sciences. 663: 154-7, 21 Nov 1992

  • Reiss K;Porcu P;Sell C;Pietrzkowski Z;Baserga R. The insulin-like growth factor 1 receptor is required for the proliferation of hemopoietic cells. Oncogene. 7(11): 2243-8, Nov 1992

  • Porcu P;Ferber A;Pietrzkowski Z;Roberts C T;Adamo M;LeRoith D;Baserga R. The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor. Molecular and Cellular Biology. 12(11): 5069-77, Nov 1992

  • Baserga R;Reiss K;Alder H;Pietrzkowski Z;Surmacz E. Inhibition of cell cycle progression by antisense oligodeoxynucleotides. Annals of The New York Academy of Sciences. 660: 64-9, 28 Oct 1992

  • Pietrzkowski Z;Sell C;Lammers R;Ullrich A;Baserga R. Roles of insulinlike growth factor 1 (IGF-1) and the IGF-1 receptor in epidermal growth factor-stimulated growth of 3T3 cells. Molecular and Cellular Biology. 12(9): 3883-9, Sep 1992

  • Surmacz E;Reiss K;Sell C;Baserga R. Cyclin D1 messenger RNA is inducible by platelet-derived growth factor in cultured fibroblasts. Cancer Research. 52(16): 4522-5, 15 Aug 1992

  • Sell C;Chang C D;Koniecki J;Chen H M;Baserga R. A cryptopromoter is activated in the proliferating cell nuclear antigen gene of growth arrested cells. Journal of Cellular Physiology. 152(1): 177-84, Jul 1992

  • Sell C;Chen M;Baserga R. A simple method to generate single-stranded probes for run-on transcription assays. Biotechniques. 12(5): 692, 694, May 1992

  • Alder H;Yoshinouchi M;Prystowsky M B;Appasamy P;Baserga R. A conserved region in intron 1 negatively regulates the expression of the PCNA gene. Nucleic Acids Research. 20(7): 1769-75, 11 Apr 1992

  • Pietrzkowski Z;Lammers R;Carpenter G;Soderquist A M;Limardo M;Phillips P D;Ullrich A;Baserga R. Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors. Cell Growth and Differentiation. 3(4): 199-205, Apr 1992

  • Surmacz E;Nugent P;Pietrzkowski Z;Baserga R. The role of the IGF1 receptor in the regulation of cdc2 mRNA levels in fibroblasts. Experimental Cell Research. 199(2): 275-8, Apr 1992

  • Baserga R. The double life of the IGF-1 receptor. Receptor. 2(4): 261-6, 1 Jan 1992

  • Charollais R H;Alder H;Ferber A;Koniecki J;Sell C;Baserga R. The role of the promoter in the expression of the PCNA gene. Gene Expression. 2(3): 285-96, 1992

  • Reiss K;Ferber A;Travali S;Porcu P;Phillips P D;Baserga R. The protooncogene c-myb increases the expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor messenger RNAs by a transcriptional mechanism. Cancer Research. 51(21): 5997-6000, 1 Nov 1991

  • Reiss K;Travali S;Calabretta B;Baserga R. Growth regulated expression of B-myb in fibroblasts and hematopoietic cells. Journal of Cellular Physiology. 148(3): 338-43, Sep 1991

  • Travali S;Ferber A;Reiss K;Sell C;Koniecki J;Calabretta B;Baserga R. Effect of the myb gene product on expression of the PCNA gene in fibroblasts. Oncogene. 6(6): 887-94, Jun 1991

  • Chang C D;Phillips P;Lipson K E;Cristofalo V J;Baserga R. Senescent human fibroblasts have a post-transcriptional block in the expression of the proliferating cell nuclear antigen gene. Journal of Biological Chemistry. 266(14): 8663-6, 15 May 1991

  • Pietrzkowski Z;Alder H;Chang C D;Ku D H;Baserga R. Characterization of an enhancer-like structure in the promoter region of the proliferating cell nuclear antigen (PCNA) gene. Experimental Cell Research. 193(2): 283-90, Apr 1991

  • Ku D H;Chang C D;Koniecki J;Cannizzaro L A;Boghosian-Sell L;Alder H;Baserga R. A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor. Cell Growth and Differentiation. 2(4): 179-86, Apr 1991

  • Koniecki J;Nugent P;Kordowska J;Baserga R. Effect of the SV40 T antigen on the posttranscriptional regulation of the proliferating cell nuclear antigen and DNA polymerase-alpha genes. Cancer Research. 51(5): 1465-71, 1 Mar 1991

  • Travali S;Reiss K;Ferber A;Petralia S;Mercer W E;Calabretta B;Baserga R. Constitutively expressed c-myb abrogates the requirement for insulinlike growth factor 1 in 3T3 fibroblasts. Molecular and Cellular Biology. 11(2): 731-6, Feb 1991

  • Baserga R. The cell cycle: myths and realities. Cancer Research. 50(21): 6769-71, 1 Nov 1990

  • Travali S;Koniecki J;Petralia S;Baserga R. Oncogenes in growth and development. Faseb Journal. 4(14): 3209-14, Nov 1990

  • Ku D H;Kagan J;Chen S T;Chang C D;Baserga R;Wurzel J. The human fibroblast adenine nucleotide translocator gene. Molecular cloning and sequence. Journal of Biological Chemistry. 265(27): 16060-3, 25 Sep 1990

  • Chang C D;Ottavio L;Travali S;Lipson K E;Baserga R. Transcriptional and posttranscriptional regulation of the proliferating cell nuclear antigen gene. Molecular and Cellular Biology. 10(7): 3289-96, Jul 1990

  • Ottavio L;Chang C D;Rizzo M G;Petralia S;Travali S;Baserga R. The promoter of the proliferating cell nuclear antigen (PCNA) gene is active in serum-derived cells. Biochemical and Biophysical Research Communications. 169(2): 509-16, 15 Jun 1990

  • Rizzo M G;Ottavio L;Travali S;Chang C D;Kaminska B;Baserga R. The promoter of the human proliferating cell nuclear antigen (PCNA) gene is bidirectional. Experimental Cell Research. 188(2): 286-93, Jun 1990

  • Chen S T;Chang C D;Huebner K;Ku D H;McFarland M;DeRiel J K;Baserga R;Wurzel J. A human ADP/ATP translocase gene has seven pseudogenes and localizes to chromosome X. Somatic Cell and Molecular Genetics. 16(2): 143-9, Mar 1990

  • Ottavio L;Chang C D;Rizzo M G;Travali S;Casadevall C;Baserga R. Importance of introns in the growth regulation of mRNA levels of the proliferating cell nuclear antigen gene. Molecular and Cellular Biology. 10(1): 303-9, Jan 1990

  • Sauve G J;Lipson K E;Chen S T;Baserga R. Sequence analysis of the human thymidine kinase gene promoter: comparison with the human PCNA promoter. Dna Sequence. 1(1): 13-23, 1990

  • Alder H;Chang C D;Chen S T;Beck I;Chang C Y;Baserga R. Temporary complementation of temperature-sensitive mutants of the cell cycle by transfection with a wild-type or a mutant cDNA of ADP/ATP translocase. Journal of Cellular Physiology. 141(1): 90-6, Oct 1989

  • Ku D H;Travali S;Calabretta B;Huebner K;Baserga R. Human gene for proliferating cell nuclear antigen has pseudogenes and localizes to chromosome 20. Somatic Cell and Molecular Genetics. 15(4): 297-307, Jul 1989

  • Travali S;Ku D H;Rizzo M G;Ottavio L;Baserga R;Calabretta B. Structure of the human gene for the proliferating cell nuclear antigen. Journal of Biological Chemistry. 264(13): 7466-72, 5 May 1989

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