MD/PhD Program
Program Faculty

Clicking on the faculty member's name will take you thier Faculty Interests Profile page for more information regarding thier area of research.

Emad S. Alnemri, PhD
Professor, Biochemistry & Molecular Biology

Molecular mechanisms of apoptosis; Role of inflammation in cancer
Andrew E. Aplin, PhD
Associate Professor, Cancer Biology

Mutant B-RAF and integrin signaling in melanoma
Jeffrey L. Benovic, PhD
Professor and Chair, Biochemistry & Molecular Biology

Dysregulation of G protein signaling in cancer
Jonathan R. Brody, PhD D
Assistant Professor, Surgery

Dysregulation of G protein signaling in cancer
Bruno Calabretta, MD, PhD
Professor, Cancer Biology

Mechanisms of leukemogenesis by oncogenic tyrosine kinases
Gino Cingolani, PhD
Associate Professor, Biochemistry & Molecular Biology

Nucleocytoplasmic transport; Virus assembly; Multisubunit ATPases; Structural and biophysical techniques
Manuel L. Covarrubias, MD, PhD
Professor, Neuroscience

Function, structure and pharmacology of voltage-gated ion channels in excitable tissues
Laurence C. Eisenlohr, VMD, PhD
Professor, Microbiology & Immunology

Antigen processing and presentation; Anti-viral responses; Vaccine development; tolerance and autoimmunity; Cancer immunotherapy
Andrzej Fertala, PhD
Professor, Orthopaedic Surgery

Heritable diseases of connective tissues.
Mark E. Fortini, PhD
Associate Professor, Biochemistry & Molecular Biology

Notch receptor signaling in tissue formation; Biochemical and cell biological events regulating Notch activation
Noreen J. Hickok, PhD
Associate Professor, Orthopaedic Surgery

Bone-bacterial-biomaterial interface; Mechanisms of bacterial colonization and biofilm formation; Therapies to interrupt bacterial adhesion and host tissue colonization
Jan B. Hoek, PhD
Professor, Pathology, Anatomy & Cell Biology

Effects of ethanol on integrated signaling responses in liver; Cell signaling and mitochondrial function; Signaling associated with liver homeostasis, stress responses, and regeneration
Michael Holinstat, PhD
Assistant Professor, Medicine, Division of Hematology

Regulation of protease-activated receptor (PAR) function in the platelet; signal transduction and regulation of hemostasis and thrombosis in the platelet; Regulation of the small GTPase Rap1 in vascular function; regulation of platelet-mediated hemostasis and thrombosis and signal transduction by 12-Lipoxygenase; 12-Lipoxygenase as a novel approach to anti-platelet therapy; study how platelet function regulates the progression of a number of cardiovascular risks such as diabetes and acute coronary syndrome
D. Craig Hooper, PhD
Professor, Cancer Biology

Neuroimmunology and viral infections
Lorraine Iacovitti, PhD
Professor, Neuroscience

Stem cells to study and treat Parkinson's disease; Neuroprotective agents to treat Parkinson's Disease; Stem cells to treat stroke; Sites of adult stem cells in brain
Renato V. Iozzo, MD
Professor, Pathology, Anatomy & Cell Biology

Proteoglycan control of cancer growth and angiogenesis; Tumor microenvironment and regulation of receptor tyrosine kinases by matrix molecules
Caleb B. Kallen, MD, PhD
Associate Professor, Department of Obstetrics & Gynecology

Our lab is investigating the role of mRNA-binding proteins in obesity-related inflammatory processes with a focus on insulin sensitivity and atherosclerosis.
Karen E. Knudsen, PhD
Professor, Cancer Biology

Hormone signaling in the male reproductive tract; Impact of androgen receptor function on prostate development and disease
Bo Lu, MD
Professor, Radiation Oncology

Cancer genomics, mechanisms of therapeutic resistance of lung cancer, enhancing therapeutic ratio of lung cancer therapy through novel targets, role of immunomodulators (PD-1 and PDL-1) in lung carcinogenesis and therapy
My G. Mahoney, PhD
Associate Professor, Dermatology & Cutaneous Biology

Role of desmosomal proteins in cell adhesion, signaling, morphogenesis, and skin cancer development
Tim Manser, PhD
Professor and Chair, Microbiology & Immunology

Antigen-dependent stages of B cell differentiation leading to the generation of B cell memory
Alexander Mazo, PhD
Professor, Biochemistry & Molecular Biology

Epigenetic function of Drosophila ortholog of the MLL oncogene
James P. McGettigan, PhD
Assistant Professor, Microbiology & Immunology

Investigating vaccine-induced T and B cell responses against viral infections
Steven B. McMahon, PhD
Professor, Cancer Biology

Deregulation of the p53 and MYC transcription networks driving cancer
A. Sue Menko, PhD
Professor,Pathology, Anatomy & Cell Biology

Signaling mediating acquisition of the differentiated cell phenotype; Cell adhesion and the cytoskeleton in regulating tissue morphogenesis, regeneration, and fibrosis
Diane E. Merry, PhD
Associate Professor, Biochemistry & Molecular Biology

Molecular determinants of androgen receptor metabolism and of polyglutamine-expanded androgen receptor misfolding and aggregation
Michael O'Leary, PhD
Associate Professor, Pathology, Anatomy & Cell Biology

Molecular mechanisms of sensory transduction in the peripheral nervous system
Michael Oshinsky, PhD
Assistant Professor, Neurology

Recurrent episodic headache syndromes
John M. Pascal, PhD
Assistant Professor, Biochemistry & Molecular Biology

Structural biology and biochemistry of the DNA damage response and mechanisms for maintaining genetic integrity
Fabienne M. Paumet, PhD
Assistant Professor, Microbiology & Immunology

Role of phagocytosis in the pathogenesis of infectious diseases; Role of phagocytosis in mast cell function in allergy
Richard G. Pestell, MD, PhD
Professor and Chair, Cancer Biology

Cell cycle control in cancer.
Natalia A. Riobo, PhD
Assistant Professor, Biochemistry & Molecular Biology

Role and mechanisms of Hedgehog signaling in proliferation, survival and cell migration
Makarand V. Risbud, PhD
Professor, Orthopaedic Surgery

Intervertebral disc biology; Hypoxic tissue niches; Stem cell biology; Tissue engineering and regenerative medicine
Michael J. Root, MD, PhD
Associate Professor, Biochemistry & Molecular Biology

Mechanisms of viral and cell-cell membrane fusion; HIV entry inhibitor design and vaccine development; Osteoclast formation/macrophage fusion.
Abdolmohamad Rostami, MD, PhD
Professor and Chair, Neurology

Helper T cell subsets and their cytokines in the pathogenesis of autoimmune encephalomyelitis (EAE) and multiple sclerosis; Effect of the Bowman-Birk serine protease inhibitor on the course of EAE; Mechanisms of intravenous tolerance in EAE; Effects of interleukin-27 (IL-27) on human auto-aggressive T cells
Hallgeir Rui, M.D., PhD
Professor, Cancer Biology

Molecular biology and signaling by receptors for lactogenic hormones; Endocrine regulation of breast cancer
Jay S. Schneider, PhD
Professor, Pathology, Anatomy & Cell Biology

Parkinson's disease; Heavy metal neurotoxicity
Matthias J. Schnell, PhD
Professor, Microbiology & Immunology

Professor, Pathology, Anatomy & Cell Biology

Development of novel vaccines and viral pathogenesis
Irving M. Shapiro, PhD
Professor, Orthopaedic Surgery

Chondrocyte apoptosis and autophagy; Stem cell function in the intervertebral disc; Development of methods to attach bioactive substances to metals utilized for orthopaedic implants
Linda D. Siracusa, PhD
Professor, Microbiology & Immunology

Genetics of cancer susceptibility
Yuri K. Sykulev, MD, PhD
Professor, Microbiology & Immunology

Molecular mechanisms regulating cytotoxic T lymphocyte activity
Ross Summer, MD
Associate Professor, Medicine, Pulmonary & Critical Care

Dr Summer's laboratory focuses on lung metabolism and understanding how local and systemic metabolic derangements contribute to the onset and progression of lung diseases.
Theodore F. Taraschi, PhD
Professor, Pathology, Anatomy & Cell Biology

Role of defective DNA mismatch repair in the development of antimalarial drug resistance
Davide Trotti, PhD
Associate Professor, Neuroscience

Mechanisms of neurodegeneration in amyotrophic lateral sclerosis
Jouni Uitto, MD, PhD
Professor and Chair, Dermatology & Cutaneous Biology

Biology of connective tissue related to cutaneous diseases that increase the risk of aggressive squamous cell carcinomas
Scott A. Waldman, MD, PhD
Professor and Chair, Pharmacology & Experimental Therapeutics

Tumor suppressors and their signaling pathways in GI malignancies; Targeted diagnostics and therapeutics in cancer
Philip B. Wedegaertner, PhD
Professor, Biochemistry & Molecular Biology

Heterotrimeric G protein regulation of intracellular trafficking; Role of RhoGEFs in mitosis
Eric Wickstrom, PhD
Professor, Biochemistry & Molecular Biology

Genetic diagnosis of cancer by imaging activated mRNAs in tumors; Analysis of circulating tumor cells; Genetic therapy of cancer by knockdown of activated genes and miRNAs
Edward Winter, PhD
Professor, Biochemistry & Molecular Biology

Molecular/genetic analyses of signaling and transcriptional regulation using meiotic development in S. cerevisiae as a model

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