Michael McCauley, MS
Adjunct Faculty
Education
MS, Biotechnology, Thomas Jefferson University, Philadelphia, PA - 2010
BS, Biotechnology, Thomas Jefferson University, Philadelphia, PA - 2009
Publications
- A strategy for selective deletion of autoimmunity-related t cells by pmhc-targeted delivery
- Dynamics of the HD regulatory subdomain of PARP-1; Substrate access and allostery in PARP activation and inhibition
- Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA
- Purification of DNA damage-dependent PARPs from E. coli for structural and biochemical analysis
- Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage
- Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification
- Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling
- PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain
Research Interest
- Protein and peptide chemistry
- Bioconjugation
- Targeted therapeutics
Biography
Michael McCauley has been an active scientific researcher and educator since he graduated with his master’s degree from Thomas Jefferson University in 2010. His early research focused on the intricate structure and chemical interactions of proteins and their roles in various pathologies. His current work is for a pharmaceutical discovery lab where he investigates enzymatic and chemical bioconjugation techniques with the goal of producing novel therapies to precisely target specific cells or tissues. Ultimately, the goal of this work is to move toward more effective treatments while minimizing toxic side effects. Michael has authored or co-authored several publications including peer-reviewed works and patents based off his research efforts. In addition to research, Michael has worked as an educator teaching undergraduate lab and lecture courses in chemistry, biochemistry, and anatomy. He also regularly volunteers for local elementary and high schools to speak about general science and scientific careers.