Lawrence Goldfinger, PhD
Professor, Department of Medicine
Director, Molecular Physiology & Translational Medicine PhD Program
Contact Information
Jefferson Alumni Hall
1020 Locust Street
394 JAH
Philadelphia, PA 19107
Professor, Department of Medicine
Director, Molecular Physiology & Translational Medicine PhD Program
Research & Interests:
We are seeking to understand the molecular cell biology regulating how circulating blood platelets contribute to hemostasis and thrombosis, and to apply this understanding to modulate platelet function in various contexts. Our research program spans molecular studies of control of platelet gene expression, the cell biological outcomes of this regulation, physiological studies of platelet function, and development of tools for pre-clinical applications in health and disease.
Education
PhD, Carnegie Mellon University
Publications
- Altered platelet-megakaryocyte endocytosis and trafficking of albumin and fibrinogen in RUNX1 haplodeficiency
- Plasma growth factors maintain constitutive translation in platelets to regulate reactivity and thrombotic potential
- Phosphatidylserine-blocking nanoparticles inhibit thrombosis without increased bleeding in mice
- Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in RUNX1 deficiency
- Platelet microRNAs inhibit primary tumor growth via broad modulation of tumor cell mRNA expression in ectopic pancreatic cancer in mice