Steven E. McKenzie, MD, PhD
Leandro M. Tocantins, MD - Farid I. Haurani, MD Director, Cardeza Foundation for Hematologic Research
Director, Hereditary Anemias Program
Associate Director, Hemophilia Center
Professor, Department of Medicine
Contact
Research Office
1020 Locust Street
Suite 394
Philadelphia, PA 19107
215-955-8544
215-955-9170 fax
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Steven E. McKenzie, MD, PhD
Leandro M. Tocantins, MD - Farid I. Haurani, MD Director, Cardeza Foundation for Hematologic Research
Director, Hereditary Anemias Program
Associate Director, Hemophilia Center
Professor, Department of Medicine
Research & Clinical Interests
Dr. McKenzie directs two major research projects. The first project involves vascular biology, with a focus on immune-mediated thrombocytopenia and thrombosis syndromes. This work, done in collaboration with Dr. Michael Reilly, led to the first model of heparin-induced thrombocytopenia and thrombosis. New work on effects of elevated cholesterol and athrosclerosis on HITT, and on microparticles and tissue factor, is ongoing.
Publications
- Aspirin pharmacokinetics and pharmacodynamics through gestation
- A mouse model of the protease-activated receptor 4 Pro310Leu variant has reduced platelet reactivity
- Plasma growth factors maintain constitutive translation in platelets to regulate reactivity and thrombotic potential
- Diagnostic value of antibody-induced procoagulant platelets in heparin-induced thrombocytopenia: communication from the ISTH SSC Subcommittee on Platelet Immunology
- Phosphatidylserine-blocking nanoparticles inhibit thrombosis without increased bleeding in mice