Megumi Shigematsu, PhD
Instructor
Contact
1020 Locust Street
Jefferson Alumni Hall Room 222
Philadelphia, PA 19107
215-503-5706
215-503-0466 fax
Megumi Shigematsu, PhD
Instructor
Expertise & Research Interests
Short non-coding RNAs (ncRNAs) are involved in the regulation of various cellular processes and are often associated with disease pathogenesis. My research interests lie primarily in the area of RNA biochemistry and RNA-seq to elucidate the biogenesis mechanisms and molecular functions of short ncRNAs. I have particularly focused on tRNA-derived fragments, and am interested in how tRNA fragments regulate cell proliferation in cancer cells and cell adhesion pathway in airway muscle cells in asthma. I am also interested in the regulation of endoribonucleases and aim to understand how RNases cleave substrate RNA to produce short ncRNAs.
Education
PhD, Biotechnology, University of Tokyo - 2011
MSc, Biotechnology, University of Tokyo – 2008
Most Recent Peer-Reviewed Publications
- Immunoactive signatures of circulating tRNA- and rRNA-derived RNAs in chronic obstructive pulmonary disease
- Immunostimulatory short non-coding RNAs in the circulation of patients with tuberculosis infection
- Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G
- ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing
- In vitro production and multiplex quantification of 2′,3′-cyclic phosphate-containing 5′-tRNA half molecules