Structural biology, x-ray crystallography, chromatin, histone modifying enzymes, nucleosome remodelers, gene expression, genome maintenance, parasitology, cancer biology, drug discovery.
Erik Debler, PhD
Associate Professor
Contact Information
1020 Locust Street
Room 411F JAH
Philadelphia, PA 19107
215-503-4596
215-923-2117 fax
Associate Professor
Research Interests
Education
PhD, Biophysics, The Scripps Research Institute, La Jolla - 2007
MS, Biochemistry, Freie Universitat Berlin, Germany - 2002
Fellowship
Damon Runyon Cancer Research Foundation Postdoctoral Fellowship, Rockefeller University
Most Recent Peer-Reviewed Publications
- Two DOT1 enzymes cooperatively mediate efficient ubiquitin-independent histone H3 lysine 76 tri-methylation in kinetoplastids
- The C-terminal 4CXXC-type zinc finger domain of CDCA7 recognizes hemimethylated DNA and modulates activities of chromatin remodeling enzyme HELLS
- Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules
- Structural enzymology of cholesterol biosynthesis and storage
- Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitment