Erik Debler, PhD
Associate Professor
Contact
1020 Locust Street
Room 411F JAH
Philadelphia, PA 19107
215-503-4596
215-923-2117 fax
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Erik Debler, PhD
Associate Professor
Research Interests
Structural biology, x-ray crystallography, chromatin, epigenetics, gene regulation, bromodomain, chromatin modifying enzymes, parasitology, trypanosomes, sleeping sickness, chemical biology, drug discovery
Education
PhD, Biophysics, The Scripps Research Institute, La Jolla - 2007
MS, Biochemistry, Freie Universitat Berlin, Germany - 2002
Fellowship
Damon Runyon Cancer Research Foundation Postdoctoral Fellowship, Rockefeller University
Most Recent Peer-Reviewed Publications
- Two DOT1 enzymes cooperatively mediate efficient ubiquitin-independent histone H3 lysine 76 tri-methylation in kinetoplastids
- The C-terminal 4CXXC-type zinc finger domain of CDCA7 recognizes hemimethylated DNA and modulates activities of chromatin remodeling enzyme HELLS
- Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules
- Structural enzymology of cholesterol biosynthesis and storage
- Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitment