Zheng Ruan, PhD
Assistant Professor
Contact
Zheng Ruan, PhD
Assistant Professor
Education
PhD, University of Georgia, Athens, GA - 2018
Fellowship
Postdoc, Van Andel Institute, Grand Rapids, MI - 2023
Publications
- Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309
- Inhibition of the proton-activated chloride channel PAC by PIP2
- Molecular determinants of pH sensing in the proton-activated chloride channel
- Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC
- Author Correction: Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition (Nature Structural & Molecular Biology, (2021), 28, 7, (604-613), 10.1038/s41594-021-00607-4)
Awards
- K99/R00 Pathway to Independence Award, 2022-2027
- American Heart Association Postdoctoral Fellowship, 2020-2021
- Graduate Student Excellence in Research Award 2019, University of Georgia, 2019
- Innovative and Interdisciplinary Research Grants for Doctoral Students (IIRG), University of Georgia Graduate School, 2017
- Grimes Family Distinguished Graduate Fellowship in Natural Sciences, Franklin College Grimes Award Committee, University of Georgia, 2015
Research & Clinical Interests
My research studies the molecular mechanisms of membrane receptors and channels that facilitate cellular signal transduction using a combination of computational, structural, and biochemical techniques. The overarching goal of the lab is to understand the allosteric communication that enables proteins to react to input signals precisely and how pharmacological compounds impact this process.