Adriana Mantegazza, PhD
Assistant Professor
Contact
233 South 10th Street
Bluemle Life Sciences Building, Room 708
Philadelphia, PA 19107
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Adriana Mantegazza, PhD
Assistant Professor
Education
Education
Post-doctoral fellow, Marks lab., Dept. of Pathology and Lab. Medicine, University of Pennsylvania, Philadelphia, PA, 2012
Post-doctoral fellow, Amigorena lab., Institut Curie, Paris, France, 2008
Doctoral fellowship CONICET, Ministry of Science and Technology, Argentina, 2005
Undergraduate Research Fellowship UBA, University of Buenos Aires, Argentina, 1999
Most Recent Peer-Reviewed Publications
- Examining the Kinetics of Phagocytosis-Coupled Inflammasome Activation in Murine Bone Marrow-Derived Dendritic Cells
- Dissecting Phagosomal Pattern Recognition Receptor-Dependent Signaling and Antigen MHC-II Presentation from Phagosomes in Murine Dendritic Cells
- The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells
- A guide to measuring phagosomal dynamics
- Phosphatidylinositol-4-kinase IIα licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells
University Appointment
Assistant Professor, 2021
Awards
- EMBO travel Award, oral presentation, 2019
- Foerderer Award, Children’s Hospital of Philadelphia, 2016
- Gordon Research Conference travel Award, oral presentation, 2012
- Keystone Symposia travel Award, oral presentation, 2011, 2012
- Juan Campomar Award, Instituto Leloir, Argentina, 2000
- Pharmaceutical Laboratory Bagó Award, 1999
- Honors Diploma, B.S., University of Buenos Aires, 1999
Research & Clinical Interests
The Mantegazza lab is interested in investigating mechanisms of regulation of inflammatory responses in Dendritic cells (DCs) – the main antigen-presenting cells and instructors of T cell responses –, by studying the crosstalk between phagosomes, inflammasomes and autophagy. Our current research projects aim at identifying new regulators of phagosome maturation, inflammasome activity and autophagy with the ultimate goal of tuning immune responses in DCs, to ensure proper inflammatory responses to pathogens and prevent chronic inflammation that may lead to disease (i.e. inflammatory bowel disease).