Carolina R. Melo-Silva, PhD
Instructor
Contact
233 South 10th Street
BLSB, Room 709
Philadelphia, PA 19107
Carolina R. Melo-Silva, PhD
Instructor
Education
- Postdoctoral Research, Thomas Jefferson University, Philadelphia PA, 2022
- PhD in Medical Sciences, Australian National University, Canberra ACT, Australia, 2011
- MSc in Molecular Biology, University of Brasilia, Brasilia DF, Brazil, 2007
Fellowships
- AAI Postdoctoral Fellowship, The American Association of Immunologists, 2020-2021
- Vice-Chancellor HDR Travel Grant, Australian National University, 2010
- ANU PhD Scholarship, Australian National University, 2008-2011
- ANU Supplemental Scholarship, Australian National University, 2008-2011
- Tuition Exemption Sponsorship, Australian National University, 2008-2011
- CAPES Master Fellowship, Coordination for the Improvement of Higher Education Personnel - Ministry of Education of Brazil, 2005-2007
- Institutional Scientific Initiation Scholarship Program – PIBIC, Brazilian National Council for Scientific and Technological Development – Brazil, 2003-2004
Publications
- Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node
- mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies
- Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice
- Resistance To Poxvirus Lethality Does Not Require the Necroptosis Proteins RIPK3 or MLKL
- Design and preclinical evaluation of a universal SARS-CoV-2 mRNA vaccine
- Interferon partly dictates a divergent transcriptional response in poxvirus-infected and bystander inflammatory monocytes
- Mechanisms of antiviral cytotoxic cd4 t cell differentiation
- IFN-β Acts on Monocytes to Ameliorate CNS Autoimmunity by Inhibiting Proinflammatory Cross-Talk Between Monocytes and Th Cells
- Resistance to lethal ectromelia virus infection requires Type I interferon receptor in natural killer cells and monocytes but not in adaptive immune or parenchymal cells
- Defective early innate immune response to ectromelia virus in the draining lymph nodes of aged mice due to impaired dendritic cell accumulation
- Chronic lymphocytic choriomeningitis infection causes susceptibility to mousepox and impairs natural killer cell maturation and function
- Loss of resistance to mousepox during chronic lymphocytic choriomeningitis virus infection is associated with impaired T-cell responses and can be rescued by immunization
- Cutting Edge: Protection by Antiviral Memory CD8 T Cells Requires Rapidly Produced Antigen in Large Amounts
- A pro-survival role for the intracellular granzyme B inhibitor Serpinb9 in natural killer cells during poxvirus infection
- Ectromelia virus N1L is essential for virulence but not dissemination in a classical model of mousepox
- The Ectromelia virus SPI-2 protein causes lethal mousepox by preventing NK cell responses
- Engineering recombinant poxviruses using a compact GFP-blasticidin resistance fusion gene for selection
- Characterization of hantaviruses circulating in Central Brazil
Research & Clinical Interests
Dedicated and passionate immunologist who genuinely believes Medical Research is essential for economic development and for improving lives. Strongly trained in Genome editing and Immunology, with focus in Viral Immunology. Strong record of designing, performing and analyzing experiments, as well as establishing novel experimental methods. Capable of working independently and in collaboration with multidisciplinary teams. Interested in early drug development and validation of novel therapeutics within pre-clinical models.