Rajanikanth Vadigepalli, PhD
Professor
Vice Chair for Research
Contact Information
1020 Locust Street
Jefferson Alumni Hall, Suite 314C
Philadelphia, PA 19107
215-955-0576
215-503-2636 fax
Professor
Vice Chair for Research
Research & Clinical Interests
We are interested in understanding the operational principles of mammalian tissue plasticity, renewal, repair and regeneration. A key goal is to develop novel clinical interventions and decision-support systems for regenerative medicine. Our transdisciplinary systems biology strategy integrates computational modeling, systems engineering, bioinformatics, functional genomics, high-dimensional data analysis, and single cell scale experimentation. Ongoing collaborative projects focus on liver repair and regeneration, alcoholic liver disease, brainstem neuroinflammation and neuroimmune processes leading to hypertension, cell fate regulation underlying developmental defects, and network modeling of renewal and regeneration in multiple mammalian tissues.
Click here for Vadigepalli Laboratory.
Education
PhD, Chemical Engineering, University of Delaware (2001)
BTech, Chemical Engineering, Indian Institute of Technology Madras (1996)
Most Recent Peer-Reviewed Publications
- From sampling to simulating: Single-cell multiomics in systems pathophysiological modeling
- Integrated transcriptomics and histopathology approach identifies a subset of rejected donor livers with potential suitability for transplantation
- Unpacking the multimodal, multi-scale data of the fast and slow lanes of the cardiac vagus through computational modelling
- Multi-organ gene expression analysis and network modeling reveal regulatory control cascades during the development of hypertension in female spontaneously hypertensive rat
- Neuromodulatory co-expression in cardiac vagal motor neurons of the dorsal motor nucleus of the vagus