Sara Meyer, PhD
Assistant Professor
Contact Information
Assistant Professor
Education
PhD, Cancer and Cell Biology, University of Cincinnati, 2009
BS, Molecular and Cellular Biology, Ohio University, 2004
Most Recent Peer-Reviewed Publications
- In vivo models of subclonal oncogenesis and dependency in hematopoietic malignancy
- FLT3 tyrosine kinase inhibition modulates PRC2 and promotes differentiation in acute myeloid leukemia
- miR-196b-Oct1/2 axis regulates DNMT3A-mutant AML pathogenesis
- Context is key for FLT3-ITD
- miR-196b-TLR7/8 Signaling Axis Regulates Innate Immune Signaling and Myeloid Maturation in DNMT3A-Mutant AML
Research Interests
Our group is interested in understanding the molecular mechanisms that contribute to myeloid leukemogenesis, with an emphasis on identifying new opportunities for therapeutic intervention. We are currently focused on characterizing how non-coding RNA, including lncRNA and miRNA, promote malignant phenotypes of cell growth, survival, and self-renewal in normal hematopoietic stem cells and leukemia cells. Another main focus of our research aims to better understand the disease mechanisms of a specific subgroup of acute myeloid leukemia (AML) harboring mutations in the epigenetic modifiers DNMT3A and TET2, and how the regulatory action of non-coding RNA impacts the epigenetic state of AML. Importantly, all of our research has a common underlying goal to exploit these mechanisms as possible therapies to induce leukemia cell death and/or differentiation.