Karin Borgmann-Winter, MD, MS

Psychiatry
Child and Adolescent Psychiatry

• 2020 T.E.A.M. Award for Teaching, Educating and Mentoring in Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Thomas Jefferson University
• 2016 Teaching/Mentoring Award, Child and Adolescent Psychiatry Training Program, Department of Child and Adolescent Psychiatry, The Children's Hospital of Philadelphia
• 2012 The Elizabeth B. Weller Distinguished Teaching Award, Child and Adolescent Psychiatry Training Program, Department of Child and Adolescent Psychiatry and Behavioral Sciences, The Children's Hospital of Philadelphia
• 2011 The Elizabeth B. Weller Distinguished Teaching Award, Child and Adolescent Psychiatry Training Program, Department of Child and Adolescent Psychiatry and Behavioral Sciences, The Children's Hospital of Philadelphia
• 2008 Teaching/Mentoring Award, Child and Adolescent Psychiatry Training Program- Children's Hospital of Philadelphia
• 2008-2010 Institute for Translational Medicine and Therapeutics Fellowship
• 2005 NARSAD Young Investigator Award
• 2002 Resident of the Year Award- Regional Council of Child and Adolescent Psychiatry of Eastern Pennsylvania and Southern New Jersey
• 2000 Resident Achievement Award-Philadelphia Psychiatric Society
• 1986 College Honors and Departmental Honors - Earlham College
• 1986 Phi Beta Kappa

My research program examines developmental foundations of psychiatric and neurodevelopmental disorders in children and adolescents. These kinds of studies require access to tissues from patients at various developmental stages as psychiatric illnesses unfold. I have pursued two lines of investigation: a) olfactory neuroepithelial biopsy studies in patients with psychosis, depression, and bipolar disorder and b) animal studies that examine specific findings identified in human tissue studies.

1. Hahn Chang-Gyu, Han Li-Ying, Rawson Nancy E, Mirza Natasha, Borgmann-Winter Karin, Lenox Robert H, Arnold Steven E: In vivo and in vitro neurogenesis in human olfactory epithelium. The Journal of Comparative Neurology 483(2): 154-63, Mar 2005.

2. Hahn Chang-Gyu, Wang Hoau-Yan, Cho Dan-Sung, Talbot Konrad, Gur Raquel E, Berrettini Wade H, Bakshi Kalindi, Kamins Joshua, Borgmann-Winter Karin E, Siegel Steven J, Gallop Robert J, Arnold Steven E: Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nature Medicine 12(7): 824-8, Jul 2006.

3. Hahn, C.G., Wang, H.Y., Cho, D.S., Talbot, K., Gur, R.E., Berrettini, W.H., Bakshi, K., Kamins, J., Borgmann-Winter, K.E., Siegal, S.J., Gallop, R.J., Arnold, S.E.: Abnormally enhanced neuregulin 1 - erB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nature Medicine 12(7): 824-828, July 2006.

4. Borgmann-Winter K E, Rawson N E, Wang H-Y, Wang H, Macdonald M L, Ozdener M H, Yee K K, Gomez G, Xu J, Bryant B, Adamek G, Mirza N, Pribitkin E, Hahn C-G: Human olfactory epithelial cells generated in vitro express diverse neuronal characteristics. Neuroscience 158(2): 642-53, Jan 2009.

5. Hahn Chang-Gyu, Banerjee Anamika, Macdonald Matthew L, Cho Dan-Sung, Kamins Joshua, Nie Zhiping, Borgmann-Winter Karin E, Grosser Tilo, Pizarro Angel, Ciccimaro Eugene, Arnold Steven E, Wang Hoau-Yan, Blair Ian A: The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses. PloS one 4(4): e5251, April 16, 2009.

6. Turetsky Bruce I, Hahn Chang-Gyu, Borgmann-Winter Karin, Moberg Paul J: Scents and nonsense: olfactory dysfunction in schizophrenia. Schizophrenia bulletin 35(6): 1117-31, Nov 2009.

7. Banerjee, A., MacDonald, M.L., Borgmann-Winter, K.E., Hahn, C.G.: Neuregulin 1-erbB4 in schizophrenia: from genes to an interactome. Brain Research Bulletin 83(3-4): 132-139, September 30, 2010.

8. Kamath Vidyulata, Turetsky Bruce I, Calkins Monica E, Kohler Christian G, Conroy Catherine G, Borgmann-Winter Karin, Gatto Dana E, Gur Raquel E, Moberg Paul J: Olfactory processing in schizophrenia, non-ill first-degree family members, and young people at-risk for psychosis. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 15(3): 209-18, Nov 2011.

9. Goldenberg Paula C, Calkins Monica E, Richard Jan, McDonald-McGinn Donna, Zackai Elaine, Mitra Nandita, Emanuel Beverly, Devoto Marcella, Borgmann-Winter Karin, Kohler Christian, Conroy Catherine G, Gur Ruben C, Gur Raquel E: Computerized neurocognitive profile in young people with 22q11.2 deletion syndrome compared to youths with schizophrenia and at-risk

for psychosis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 159B(1): 87-93, Jan 2012.

10. Algon Sibel, Yi James, Calkins Monica E, Kohler Christian, Borgmann-Winter Karin E: Evaluation and treatment of children and adolescents with psychotic symptoms. Current psychiatry reports 14(2): 101-10, Apr 2012.

11. Kamath Vidyulata, Moberg Paul J, Calkins Monica E, Borgmann-Winter Karin, Conroy Catherine G, Gur Raquel E, Kohler Christian G, Turetsky Bruce I: An odor-specific threshold deficit implicates abnormal cAMP signaling in youths at clinical risk for psychosis. Schizophrenia research 138(2-3): 280-4, Jul 2012.

12. Brown Alan S, Borgmann-Winter Karin, Hahn Chang-Gyu, Role Lorna, Talmage David, Gur Raquel, Chow Jacky, Prado Patric, McCloskey Thelma, Bao Yuanyuan, Bulinski J Chloe, Dwork Andrew J: Increased Stability of Microtubules in Cultured Olfactory Neuroepithelial Cells from Individuals with Schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry October 24, 2013 Notes: Epub ahead of printpii: S0278-5846(13)00236-4. doi: 10.1016/j.pnpbp.2013.10.015.

13. Kamath Vidyulata, Turetsky Bruce I, Calkins Monica E, Bilker Warren B, Frishberg Nathan, Borgmann-Winter Karin, Kohler Christian G, Conroy Catherine G, Gur Raquel E, Moberg Paul J: The effect of odor valence on olfactory performance in schizophrenia patients, unaffected relatives and at-risk youth. Journal of Psychiatric Research 47(11): 1636-41, Nov 2013.

14. Moberg Paul J, Kamath Vidyulata, Marchetto Dana M, Calkins Monica E, Doty Richard L, Hahn Chang-Gyu, Borgmann-Winter Karin E, Kohler Christian G, Gur Raquel E, Turetsky Bruce I: Meta-analysis of olfactory function in schizophrenia, first-degree family members, and youths at-risk for psychosis. Schizophrenia bulletin 40(1): 50-9, Jan 2014.

15. Kamath V, Turetsky BI, Calkins ME, Kohler CG, Conroy CG, Borgmann-Winter K, Gatto, DE, Gur RE, Moberg PJ: Olfactory processing in schizophrenia, non-ill first-degree members and young people at risk for psychosis. World Journal of Biological Psychiatry 15(3): 209-18, April 2014.

16. Kohler Christian G, Richard Jan A, Brensinger Colleen M, Borgmann-Winter Karin E, Conroy Catherine G, Moberg Paul J, Gur Ruben C, Gur Raquel E, Calkins Monica E: Facial emotion perception differs in young persons at genetic and clinical high-risk for psychosis. Psychiatry research 216(2): 206-12, May 2014.

17. Borgmann-Winter K, Willard S L, Sinclair D, Mirza N, Turetsky B, Berretta S, Hahn C-G: Translational potential of olfactory mucosa for the study of neuropsychiatric illness. Translational psychiatry 5: e527, Mar 2015.

18. Tatard-Leitman Valerie M, Jutzeler Catherine R, Suh Jimmy, Saunders John A, Billingslea Eddie N, Morita Susumu, White Rachel, Featherstone Robert E, Ray Rabindranath, Ortinski Pavel I, Banerjee Anamika, Gandal Michael J, Lin Robert, Alexandrescu Anamaria, Liang Yuling, Gur Raquel E, Borgmann-Winter Karin E, Carlson Gregory C, Hahn Chang-Gyu, Siegel Steven J: Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability. Biological psychiatry 77(6): 556-68, Mar 2015.

19. Banerjee A, Wang H-Y, Borgmann-Winter K E, MacDonald M L, Kaprielian H, Stucky A, Kvasic J, Egbujo C, Ray R, Talbot K, Hemby S E, Siegel S J, Arnold S E, Sleiman P, Chang X, Hakonarson H, Gur R E, Hahn C-G: Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia. Molecular psychiatry 20(9): 1091-100, Sep 2015.

20. Egbujo Chijioke N, Sinclair Duncan, Borgmann-Winter KE, Arnold Steven E, Turetsky Bruce I, Hahn Chang-Gyu: Molecular evidence for decreased synaptic efficacy in the postmortem olfactory bulb of individuals with schizophrenia. Schizophrenia research 168(1-2): 554-62, Oct 2015.

21. Borgmann-Winter KE, Wang Hoau-Yan, Ray Rabindranath, Willis Brooke R, Moberg Paul J, Rawson Nancy E, Gur Raquel E, Turetsky Bruce I, Hahn Chang-Gyu: Altered G Protein Coupling in Olfactory Neuroepithelial Cells From Patients With Schizophrenia. Schizophrenia bulletin 42(2): 377-85, Mar 2016.

22. Sinclair Duncan, Cesare Joseph, McMullen Mary, Carlson Greg C, Hahn Chang-Gyu, Borgmann-Winter KE: Effects of sex and DTNBP1 (dysbindin) null gene mutation on the developmental GluN2B-GluN2A switch in the mouse cortex and hippocampus. Journal of neurodevelopmental disorders 8(14): 14, May 2016.

23. Schoch Hannah, Kreibich Arati S, Ferri Sarah L, White Rachel S, Bohorquez Dominique, Banerjee Anamika, Port Russell G, Dow Holly C, Cordero Lucero, Pallathra Ashley A, Kim Hyong, Li Hongzhe, Bilker Warren B, Hirano Shinji, Schultz Robert T, Borgmann-Winter K, Hahn Chang-Gyu, Feldmeyer Dirk, Carlson Gregory C, Abel Ted, Brodkin Edward S: Sociability Deficits and Altered Amygdala Circuits in Mice Lacking Pcdh10, an Autism Associated Gene. Biological psychiatry 81(3): 193-202, Feb 2017.

24. Wang Hoau-Yan, MacDonald Matthew L, Borgmann-Winter KE, Banerjee Anamika, Sleiman Patrick, Tom, A, Khan, A, Lee, KC, Roussos Panos, Siegel Steven J, Hemby, Scott E, Bilker Warren B, Gur Raquel E, Hahn Chang-Gyu. mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia. Molecular Psychiatry. 2018 Sep 13. [Epub ahead of print]

25. Ward KR, Featherstone RE, Naschek MJ, Melnychenko O, Banerjee A, Yi J, Gifford RL, Borgmann-Winter, KE, Salter MW, Hahn CG, Siegel SJ. Src deficient mice demonstrate behavioral and electrophysiological alterations relevant to psychiatric and developmental disease. Progress in Neuropsychopharmacology and Biological Psychiatry. 2019 Feb 28;93:84-92. [Epub ahead of print]

26. Borgmann-Winter, KE, Wang, Kai, Bandyopadhyay Sabyasachi, Doostparast Torshizi, Abolfazl, Hahn, Chang-Gyu. Proteomics and its dynamics: A missing piece for integrative multi-omics in Schizophrenia. Schizophrenia Research 217:148-161, Mar, 2020.

1. Borgmann-Winter Karin, Calkins Monica E, Kniele Kathryn, Gur Raquel E: Assessment of adolescents at risk for psychosis. Current psychiatry reports 8(4): 313-21, Aug 2006.

2. Banerjee Anamika, Macdonald Mathew L, Borgmann-Winter Karin E, Hahn Chang-Gyu: Neuregulin 1-erbB4 pathway in schizophrenia: From genes to an interactome. Brain research bulletin 83(3-4): 132-9, Apr 2010.

3. Weaver Laurel A, De León Diva D, Borgmann-Winter Karin, Coffey Barbara J: Use of metformin to control clozapine-associated weight gain in an adolescent with schizoaffective disorder. Journal of child and adolescent psychopharmacology 20(2): 153-7, Apr 2010.

4. Elia Josephine, Wilson Zoe, La Porta Lilly Sehgal, Algon Sibel A, Prowler Matthew L, Cartwright Shanique T, McKenna Patricia A, Laracy Seth, Takeda Toshinobu, Borgmann-Winter Karin: Methylphenidate transdermal system: clinical applications for attention-deficit/hyperactivity disorder. Expert review of clinical pharmacology 4(3): 311-28, May 2011.

5. Algon, S., Yi, J., Calkins, M.E., Kohler, C., Borgmann-Winter, K.E: Evaluation of children and adolescents with psychotic symptoms. Current Psychiatry Reports 14(2): 101-110, April 2012.

6. Elia Josephine, Sackett Jillan, Turner Terri, Schardt Martin, Tang Shih-Ching, Kurtz Nicole, Dunfey Maura, McFarlane Nadia A, Susi Aita, Danish David, Li Alice, Nissley-Tsiopinis Jenelle, Borgmann-Winter Karin: Attention-deficit/hyperactivity disorder genomics: update for clinicians. Current Psychiatry Reports 14(5): 579-89, Oct 2012.

7. Elia Josephine, Laracy Seth, Allen Jeremy, Nissley-Tsiopinis Jenelle, Borgmann-Winter Karin: Epigenetics: genetics versus life experiences. Current topics in behavioral neurosciences 9: 317-40, 2012.

8. Kohler Christian, Borgmann-Winter Karin E, Hurford Irene, Neustadter Eli, Yi James, Calkins Monica E: Is prevention a realistic goal for schizophrenia? Current psychiatry reports 16(4): 439, Apr 2014.