The major goal of my research program is to understand molecular mechanisms regulating various activities of cytotoxic lymphocytes. Understanding of these mechanisms, particularly those that lead to the lymphocyte activation and inactivation, is expected to facilitate the development of novel approaches to manipulate lymphocytes receptor-mediated signaling and their responsiveness and would lead to the development of novel immunotherapeutic interventions to treat viral infections, cancer and other diseases.
Yuri K. Sykulev, MD, PhD
Professor, Department of Microbiology & Immunology
Contact Information
233 South 10th Street
Bluemle Life Sciences Building 706
Philadelphia, PA 19107
215-503-4530
215-923-4153 fax
Professor, Department of Microbiology & Immunology
Expertise & Research Interests
Publications
- The FcγRIIIA (CD16) L48-H/R Polymorphism Enhances NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity by Promoting Serial Killing
- The role of peptide conformation presented by MHC in the induction of TCR triggering
- Factors contributing to the potency of CD8+ T cells
- The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection
- Efficient killing of tumor cells by CAR-T cells requires greater number of engaged CARs than TCRs