The LISI Project (PI: Myers)  - Receptiveness of primary care patients to clinical trial enrollment

This two-year pilot study assesses whether primary care patients are receptive to being participants in a clinical trial that will test the safety and efficacy of a new blood test that can detect multiple different types of cancer. The study used surveys and interviews in 1,000 patients across 4 different primary care practice sites.

• The LISI Project helps us to understand what is important to people who seek care in our primary care system as they consider entering a clinical trial.
• The study lays the groundwork for patient-centered approaches to large clinical trials on topics of importance to the communities we serve.

The SOAR Trial (PI: Chambers) – Clinical trial of multi-cancer detection (MCED) blood testing[AF1]

This large, 5-year randomized controlled trial will enroll 10,000 diverse patients ages 50-84 years old, across 50 primary care sites within Jefferson Primary Care. It will test the safety and effectiveness of a new multi-cancer detection (MCED) blood test. In designing this study, our investigators paid special attention to developing best practices for large-scale clinical trials in primary care.

• The SOAR trial establishes Jefferson Primary Care as an entity able to conduct very large clinical trials in a real-world primary care environment.
• The study positions Jefferson Primary Care as a national leader in the design of high-quality, patient-centered clinical trials, including in the important area of cancer detection.

IMPLEMENTING PREVENTIVE CARE RECOMMENDATIONS
 

The MAPPS Trial (PI: Myers) – Improving lung cancer screening rates

This 5-year randomized trial will test whether support for clinical providers and/or patient outreach can increase lung cancer screening rates in primary care. Nationally, lung cancer screening rates are far below the recommended levels. The trial will include 28 primary care practices and 672 patients across four health systems, including Jefferson Primary Care.

·         The MAPPS trial helps us to understand how we can support primary care teams in delivering recommended preventive services to our patients in a consistent and effective way.

COMMUNITY HEALTH WORKERS, DIABETES, AND AGING

The Diabetes Regulation for Eyesight and Memory (DREAM) Study (PI: Rovner)

This randomized control trial that tests whether DM-Specific Behavioral Activation (DM-BA), a special type of cognitive behavioral therapy, can prevent a decline in verbal memory in older adults with memory loss and poorly controlled diabetes. The therapy is delivered by community health workers as well as through a telehealth visit with a diabetes nurse educator. The study will enroll 200 African-American patients ages 65 and older from practices across Jefferson Primary Care.

·         The DREAM Study helps us understand how different types of treatment, including behavioral health interventions led by community health workers, can improve both chronic disease and memory loss.